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Kaligialitin o'simta antibiotikli sitotoksik vosita

Kaligialitin o'simta antibiotikli sitotoksik vosita

Ingliz tili: Kaligialitsin
CAS raqami: 108212-75-5
Boshqa ismi:
calicheamicin gamma(1)I; Benzenecarbothioic acid, 4-((6-deoxy-3-o-methyl-alpha-L-mannopyranosyl)oxy)-3-iodo-5,6-dimethoxy-2-methyl-, 4''-ester with methyl (8-((4,6-dideoxy-2-o-(2,4-dideoxy-4-(ethylamino)-3-o-methyl-alpha-L-threo-pentapyranosyl)-4-(((2,6-dideoxy-4-thio-beta-D-ribo-hexopyranosyl)oxy)amino)-beta-D-glucopyranosyl)oxy)-1-hydroxy-13-(2-(methyltrithio)ethylidene)-11-oxobicyclo(7.3.1)trideca-4,9-diene-2,6-diyn-10-yl)carbamate, (1R-(1R*,4Z,8S*,13E))-; Calichemicin gamma1; Carbamic acid, ((1R,4Z,8S,13E)-8-((4,6-dideoxy-4-(((2,6-dideoxy-4-S-(4-((6-deoxy-3-o-methyl-alpha-L-mannopyranopyranosyl)oxy)-3-iodo-5,6-dimethoxy-2-methylbenzoyl)-4-thio-beta-D-ribo-hexopyranosyl)oxy)amino)-2-o-(2,4-dideoxy-4-(ethylamino)-3-o-methyl-alpha-L-threo-pentopyranosyl)-beta-D-glucopyranosyl)oxy)-1-hydroxy-13-(2-(methyltrithio)ethylidene)-11-oxobicyclo(7.3.1)trideca-4,9-diene-2,6-diyn-10-yl)-, methyl ester; Calicheamicin γ1; LL-E 33288 gamma1-I; calicheamicin gamma; Calicheamicin γ1 purity>95
So'rov yuborish

Mahsulot tavsifi

 

Ingliz tili: Kalimurikachin

CAS raqami: 108212-75-5

Molekulyar formula: c55h74in3o21s4

Molekulyar og'irlik: 1,368.34

Eynecs yo'q:

Tegishli toifalar: API [faqat ilmiy tadqiqotlar uchun]; farmatsevtika API; ilmiy tadqiqotlar faol dori seriyali; API; API va vositachilar; reagentlar; boshqalar; Kimyoviy reagentlar; ADC; Farmatsevtika

Mol fayli: 108212-75-5. Mol

 

Molekulyar tuzilma:

1 -

 

Kalitromitsin xususiyatlari

Xususiy aylanish: d 26-124 (c=0. 98%, etoh)

Zichlik: 1,57 {0. 1 g / sm3 (bashorat qilingan)

Saqlash shartlari: -20 c

Solubatuallik: DMSO: 100 mg / ml (73,08 mm); Suv:<0.1 mg / mL (insoluble)

Shakl: qattiq

Amaliyot koeffitsichini (PK A): 7.13 {{2} {{{{{{2. bashorat qilingan)

Rang: oqgacha oq

 

Kalitimbolitinning metodikasi va sintez usuli

 

Qisqa kirish

Kaligialarcinlins (CLAM) - bu kamdan-kam kichik monosporumning fermentatsiyasidan ajratilgan endiyn antibiotiklar.

 

Harakat mexanizmi

Carchitromitsinning bioaktiv konsentratsiyasi<1 PgmL-1 had extremely potent killing effects in leukemia such as lymphocytic leukaemia P388 and L1210 cells as well as solid tumors such as colon cancer 26 and melanoma B-16 cells. The biological activity of cazithromycin mainly by combining cellular DNA with the Chemicalbook minor groove, directly break cell DNA, further induce tumor cell apoptosis, at the same time, cazithromycin has nonspecific damage effect on cellular RNA, Mylotarg with CD33 monoclonal antibody conjugate is the first approved by the FDA for tumor treatment, has been used in clinical practice.

 

Foydalanish

Ckitromitsin - bu DNK ikki shpunni buzishga olib keladigan kuchli sitotoksik vositadir.

 

Toksiklik

Kachitromitsin juda zaharli va tuproq bakteriyalari tomonidan ishlab chiqarilgan yuzlab metabolitlardan biridir.

 

Bioaktivlik

KaligiaMicin - bu o'simta antibiotik, shuningdek, DNK ikki shpalni buzadigan kuchli sitotoksik vositadir. KaligiaMicin DNK sintezini inhibelash.

 

Maqsadli joy

Kaligialininlar

 

Vitro darsda

Pf {{{{{{{{{28 {{{{{{{{{{4- lice) ISGerededViaconjugeFhe22LlySinezeestHeabutheMh-N-AC -calikeaicinin - 1 Linker-NetowoadwarwAwgugg-ga-antikodratio (Dar )4.6.pf -06647263 elititsa ntigen-anconctsionctionctiontivlik, asexposuretopf -06647263} form / {16}} -06647263 ni tasdiqlash uchun ({2}} -544, ISeftoremicalin, ISeftoremicine bronceinpeiatrikpimaryb-calerecurerworkutemfopllastemiya (BCP-barchasi) -544 indukrinallinelinelinelinelinelineinlineinline-vatialadveineineineineineineineineineineineineineineineineineineineinewineineineinewineineineinewneineineining OM0.15T4.9NG / ML.CMC -544 (10ng / ml) {32} Tedcells, Theevelofcd22hasdecrReRerathRereletTotong5 / {38} {{38} {{38} {{{38} {{{38} {{44- TEXNIKADICONDETODEHROGRILIShI.

 

Vivo tadqiqotida

Anadcompenmenmenmenumanizatsiyaganiantionti-efna4monokloalantJugeJugeJugeJugenojnoedtotedytotedybucotedythedjnamieacheacheacheacheieMacheieMamuxum-ning PoycassionBotThThCandovadiantcvinViviarivVivoVivowarivVivo.pf 0 (0 (0 (0 2. 0

 

Issiq teglar: Kaligialinin o'sma antibiotikli sitotoksik vosita, Xitoy Kaligialitin o'simta tematik antibiotikli sitotoksik vosita etkazib beruvchilari